Wednesday, November 30, 2011

The Eyes Have It...

Internet Debris

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Genetic mutation makes 

those brown eyes blue

                     By Jeanna Bryner
Carolyn Kaster / AP file

Scientists find that blue-eyed individuals have a single, common ancestor

How did actress Reese Witherspoon get those big blue eyes? A team of scientists has found that blue eyes are linked to a genetic mutation that occurred between 6,000 and 10,000 years ago.
People with blue eyes have a single, common ancestor, according to new research.
A team of scientists has tracked down a genetic mutation that leads to blue eyes. The mutation occurred between 6,000 and 10,000 years ago, so before then, there were no blue eyes.
"Originally, we all had brown eyes," said Hans Eiberg from the Department of Cellular and Molecular Medicine at the University of Copenhagen.
The mutation affected the so-called OCA2 gene, which is involved in the production of melanin, the pigment that gives color to our hair, eyes and skin.
"A genetic mutation affecting the OCA2 gene in our chromosomes resulted in the creation of a 'switch,' which literally 'turned off' the ability to produce brown eyes," Eiberg said.
The genetic switch is located in the gene adjacent to OCA2 and rather than completely turning off the gene, the switch limits its action, which reduces the production of melanin in the iris. In effect, the turned-down switch diluted brown eyes to blue.
If the OCA2 gene had been completely shut down, our hair, eyes and skin would be melanin-less, a condition known as albinism.
Baby blues "It's exactly what I sort of expected to see from what we know about selection around this area," said John Hawks of the University of Wisconsin-Madison, referring to the study results regarding the OCA2 gene. Hawks was not involved in the current study.
Eiberg and his team examined DNA from mitochondria, the cells' energy-making structures, of blue-eyed individuals in countries including Jordan, Denmark and Turkey. This genetic material comes from females, so it can trace maternal lineages.
They specifically looked at sequences of DNA on the OCA2 gene and the genetic mutation associated with turning down melanin production.
Over the course of several generations, segments of ancestral DNA get shuffled so that individuals have varying sequences. Some of these segments, however, that haven't been reshuffled are called haplotypes. If a group of individuals shares long haplotypes, that means the sequence arose relatively recently in our human ancestors. The DNA sequence didn't have enough time to get mixed up.
Melanin switch "What they were able to show is that the people who have blue eyes in Denmark, as far as Jordan, these people all have this same haplotype, they all have exactly the same gene changes that are all linked to this one mutation that makes eyes blue," Hawks said in a telephone interview.
The mutation is what regulates the OCA2 switch for melanin production. And depending on the amount of melanin in the iris, a person can end up with eye color ranging from brown to green. Brown-eyed individuals have considerable individual variation in the area of their DNA that controls melanin production. But they found that blue-eyed individuals only have a small degree of variation in the amount of melanin in their eyes.
"Out of 800 persons we have only found one person which didn't fit — but his eye color was blue with a single brown spot," Eiberg told LiveScience, referring to the finding that blue-eyed individuals all had the same sequence of DNA linked with melanin production.
"From this we can conclude that all blue-eyed individuals are linked to the same ancestor," Eiberg said. "They have all inherited the same switch at exactly the same spot in their DNA." Eiberg and his colleagues detailed their study in the Jan. 3 online edition of the journal Human Genetics.
That genetic switch somehow spread throughout Europe and now other parts of the world.
"The question really is, 'Why did we go from having nobody on Earth with blue eyes 10,000 years ago to having 20 or 40 percent of Europeans having blue eyes now?" Hawks said. "This gene does something good for people. It makes them have more kids."

Story via Live Science
Doctor claims he can turn brown eyes blue (but he can't change them back again)

Procedure takes just 20 seconds

  • Ever wished you were the blue-eyed boy? You soon could be, after a doctor revealed he can permanently change a person's eye colour in just 20 seconds.
    Dr Gregg Homer, from Stroma Medical in California said his Lumineyes technology uses a laser tuned to a specific frequency to turn brown eyes to blue.
    The laser energy removes the brown pigment, or melanin, from the top layer of the iris, and the blue eye colour emerges over the following two to three weeks.
The Lumineye technology works by removing some of the brown pigment from the front of the iris, leaving it blue
The Lumineye technology works by removing some of the brown pigment from the front of the iris, leaving it blue. In this picture the process has been performed on the bottom half of the eye. It would provide an alternative to those who wanted lighter eyes without resorting to cosmetic contact lenses. However the procedure - which Dr Homer has developed over 10 years - is irreversible because the brown tissue cannot regenerate.
Stroma Medical has started limited human testing but is seeking up to £500,000 to complete clinical trials. If all goes to plan Dr Homer says the procedure could be available outside the U.S within 18 months and inside the U.S in three years.
    The former entertainment lawyer said the operation would cost around £3,000.
    Dr Homer told KTLA Morning News that thousands of prospective clients had contacted him by email to express their interest.
    'They say the eyes are the windows to the soul,' he told 'A blue eye is not opaque, you can see deeply into it, while a brown eye is very opaque. I think there is something very meaningful about this idea of having open windows to the soul.'
    lumineyegregg homer
    Dr Gregg Homer (right) has developed the technology over 10 years and submitted a patent for the laser eye-pigment changer in 2005. Right - An eye towards the end of treatment CEO of Stroma Medical, Doug Daniels, admitted he wasn't sure about the concept when Dr Homer first told him about it.
    'I was very sceptical frankly, but I learned a long time ago that all the great ideas start out as blasphemy,' he said. Eye colour is inherited, however brown eyes are dominant across the world while blue eyes are a recessive trait.
    A blue eye pigment doesn't actually exist in nature. Instead, people with blue eyes have a brown pigment, known as melamin, at the back of their irises but have low concentrations of melanin in the front of their irises.
    This means longer wavelengths of light are absorbed by the dark back of the eye, while the shorter wavelengths are scattered. In 2008, scientists from the University of Copenhagen, found that all people with blue eyes were descended from a single ancestor with a blue eye mutation who lived six to 10,000 years ago.
    Study leader Professor Eiberg said before this time, everyone had brown eyes.
    The mutation of brown eyes to blue represents neither a positive nor a negative mutation. It is one of several mutations such as hair colour, baldness, freckles and beauty spots, which neither increases nor reduces a human’s chance of survival.
    Professor Eiberg said at the time: 'It simply shows that nature is constantly shuffling the human genome, creating a genetic cocktail of human chromosomes and trying out different changes as it does so.'

    Story via The Daily Mail

    Gene therapy used in a bid to save a man's sight

    Jonathan WyattJonathan Wyatt: Hoping doctors can save his sight so he can continue to work as a lawyer

    Researchers in Oxford have treated a man with an advanced gene therapy technique to prevent him from losing his sight. It is the first time that anyone has tried to correct a genetic defect in the light-sensing cells that line the back of the eye. The president of the Academy of Medical Sciences said the widespread use of gene therapy of this treatment will be soon be possible.
    The operation was carried out on 63-year-old Jonathan Wyatt, an arbitration lawyer based in Bristol. Mr Wyatt was able to see normally until about the age of 19 when he began having problems seeing in the dark. He was told by doctors that his vision would get progressively worse and he would eventually go blind.
    The gradual deterioration in his vision didn't stop Mr Wyatt from qualifying as a barrister. But 10 years ago he found he was having difficulty reading statements in dimly-lit courts. 

    "The worst occasion was when I was reading out a statement to the court and I made a mistake. The judge turned to me and snapped 'Can't you read Mr Wyatt?!' I then decided it was time to put my wig down and leave advocacy."

    Geneticist Dan Lipinski, from the University of Oxford, explains the gene therapy process. "Mr Wyatt is able to see well enough to work from home and hopes that the operation will enable him to continue his profession. Without treatment, he would be blind within a few years and would be unable to work in the way that he is doing so now. I'd like things to get a little better," he says.

    Devastating Diagnosis

    Mr Wyatt suffers from a rare genetic disorder known as Choroideraemia. These patients start off life with normal vision and its not until their late childhood that they notice that they cannot see anything at night and usually the diagnosis is made during middle to late childhood.
    From then it is a devastating diagnosis because these young people are told that they are gradually going to lose their sight completely, usually by the time they are in their 40s. There is no treatment for this condition. The disease is caused by an inherited faulty gene, called REP1. Without a functioning copy of the gene, the light detecting cells in the eye die. The idea behind the gene therapy is simple: stop the cells from dying by injecting working copies of the gene into them.

    It is the first time that anyone has attempted to correct a gene defect in the light-sensing cells that line the back of the eye. Mr Wyatt is the first of 12 patients undergoing this experimental technique over the next two years at the John Radcliffe Hospital in Oxford.
    His doctor, Prof Robert MacLaren, believes that he'll know for sure whether the degeneration in Mr Wyatt's eye has stopped within two years. If that's the case his vision will be saved indefinitely.
    "If this works with then we would want to go in and treat patients at a much earlier stage in childhood, effectively where they still have normal vision and can do normal things to prevent them from losing sight.
    Prof MacLaren believes that if this gene therapy works it could be used to treat a wide variety of eye disorders, including the most common form of blindness in the elderly, macular degeneration. "That is a genetic disease and I have no personal doubt in future that there will be a genetic treatment for it," he says.
    The Oxford research follows on from a gene therapy trial which began four years ago at Moorfields Hospital in London. The principle aim of these trials was to demonstrate that the technique was safe. The treatment, which adopted a slightly different approach, was tested first in adult patients whose sight was almost gone, and then in children.
    According to Prof Robin Ali, who led that research, the trials have shown not only that gene therapy is safe - but that there has been significant improvement in some patients. "It is very exciting to see the start of another ocular gene therapy trial and the field moving so rapidly in recent years," he said.
    "In the last 12 months, several new gene therapy trials for the treatment of various retinal disorders have been initiated and further trials are likely to start very soon. We are all looking forward to seeing the results."


    The concept of using gene therapy for treating a whole host of conditions has been around for more than 20 years. But with, some notable exceptions, it's an idea that's failed to live up to its hype. Now, however, it seems that the technique is beginning to deliver, at least in treating sight disorders.
    According to Prof Sir John Bell, president of the Academy of Medical Sciences, these very early trails in Oxford, London and in the US suggest that a whole host of sight disorders could, be treatable "within the next 10 years." ..."Of all the things that are available for this particular set of diseases this is by far the most exciting," he said.
    "This is a set of diseases where molecular medicine has reached a point where we can now intervene in a very precise way to correct the defect that caused the blindness in the first place. There is the possibility that you could actually correct the gene defect."
    The trial, led by Oxford University, has been jointly funded by the Wellcome Trust and Department of Health. It is an example of a new approach to medical research which brings together scientists and clinicians to translate basic science into effective treatments more quickly.
    "This is exactly where the NHS ought to be putting its effort and it's a perfect example of the benefits that might from using the NHS for this kind of research activity," said Prof Bell.

    Story via The BBC

    In the Autumn of 1954, all eyes were on a new kind of car  a personal luxury car  the 1955 Thunderbird

    The 1955 - 1957 Ford Thunderbirds

    Sinatra had one, Bing had one, the "mysterious blonde" in American Graffiti had one, and my father had one when I was a kid. No matter where we went, people would stop, women, young, old...didn't matter.

    If Chevrolet hadn't introduced the 1953 Corvette it's likely that Ford never would have felt compelled to develop the Thunderbird in response. But though the T-Bird was a response to it, Ford's two-seater was a distinctly different machine from GM's plastic-bodied sports car.

    First of all, the Thunderbird's body, like that of all other Fords, was made of steel. Second, the Thunderbird was available solely with a V8 engine unlike the Corvette which started life with a straight six and only added the V8 as an option for 1955. And third, the Thunderbird wasn't trying very hard to pretend it was a sports car.

    The Thunderbird went on sale October 22, 1954, and quickly overwhelmed the Corvette in sales volume. Ford had thought it would sell about 10,000 examples that first year, but found itself unable to keep up with demand and eventually knocked out 16,155 examples during the debut model year (production ran deep into September of '55 when the 1956 model Fords were already in showrooms). That was more than five times the number of Corvettes Chevrolet built that year — and all this despite a price tag that started at $2,695 but could run easily past $3,800 with options.

    This video was just too entertaining not to post...some parts may be considered inappropriate today in some my opinion it was just a simpler time. 

    To add your comments, click on 
    links to this post 
    here or below. It will take you to a stand-alone copy of this page. There, you will find the comments box at the very bottom, so feel free to let 'er rip.




    Spooooky Reading...

    Evil Little Stories: A Collection
    It's not too early to think about Christmas gifting.

    What lies beneath...

    Getting back to genetic mutations, have a look at this passion fruit!

    Image via Paul's Allotment Diary 
    Maranhao, Brazil

    No wonder she has no teeth!

    Tuesday, November 29, 2011

    This Space to Let

    Internet Debris

    A collection by Neal McKenna 

    McKenna Ink Thesis Editing Service 

    To add your comments, 

    click here.

    NOTHING posted here is mine! 

    Internet Debris does not claim rights 

    to any of the photos or media content posted to the site.

    No copyright infringement is intended.

    'Anthrax isn't scary at all compared to this':

    Man-made flu virus with potential to wipe out many millions if it ever escaped is created in research lab

    By DAILY MAIL REPORTER  November 28. 2011

    Scientist responsible is bracing himself for a media storm. 

    Just five tweaks to H5N1 makes it more contagious

    Contagious version of bird flu could cause pandemic

    Scientists divided over whether findings can be released
    A group of scientists is pushing to publish research about how they created a man-made flu virus that could potentially wipe out civilization. The deadly virus is a genetically tweaked version of the H5N1 bird flu strain, but is far more infectious and could pass easily between millions of people at a time. The research has caused a storm of controversy and divided scientists, with some saying it should never have been carried out.

    Deadly: The new strain of bird flu could wipe out millions of people at a time.
    The current strain of H5N1 has only killed 500 people and is not contagious enough to cause a global pandemic. But their are fears the modified virus is so dangerous it could be used for bio-warfare, if it falls into the wrong hands.

    Virologist Ron Fouchier of the Erasmus Medical Centre in the Netherlands lead a team of scientists who discovered that a mere five mutations to the avian virus was sufficient to make it spread far more easily. He conducted his tests on ferrets as the animals have become a model of choice for influenza and have similar respiratory tracts to humans.

    Fouchier is so prepared for a media storm that he has hired an advisor to help him work on a communication strategy. The research done was part of an international drive to understand H5N1 more fully. Fouchier admitted the strain is 'one of the most dangerous viruses you can make' but is still adamant he wants to publish a paper describing how it was done.

    The study is one of two which has caused serious debate about scientific freedom and about regulating research which might have potential public health benefits but at the same time could also be useful for bio-terrorism. The other paper, also on H5N1, was done by a joint team at the University of Wisconsin and the University of Tokyo.
    It is understood to have had comparable results to the study done by Fouchier.

    Dangerous: It is feared if new details of the avian flu is published, it could be used for bioterrorismDangerous: It is feared if new details of the avian flu is published, it could be used for bioterrorism
    Both papers are now being reviewed by the U.S National Science Advisory Board for Biosecurity (NSABB). NSABB does not have the power to prevent the publication but it could ask journals not to publish. Paul Keim, chairman of NSABB, said: 'I can't think of another pathogenic organism that is as scary as this one. I don't think anthrax is scary at all compared to this.'

    Traditionally scientific research has always been open so that fellow scientists can review the work of others and repeat their methods to try and learn from them. But numerous scientists have said they believe research on the avian flu should be suppressed.

    However bio-defense and flu expert Michael Osterholm, who is director of the Center for Infectious Disease Research and Policy at the University of innesota, said the work carried out was important medically. He added he could not discuss the papers because he was a member of NSABB but said if they were published certain information could be withheld and made available to those who really need to know. 'We don't want to give bad guys a road map on how to make bad bugs really bad,' he said.
    Text via The Daily Mail 

    Image via Media 29

    Well! That's cheery news. 
    Maybe we should simply kiss our asses goodbye and party until we drop.
    Might as well start right now.
    Puttin' On The Ritz... Again

    If you're of a certain age, you'll fondly (or not) recall Taco's smash-hit "Puttin' on the Ritz." Check him out performing it in Russia in 2009...

    From Katharine Hepburn’s 1981 interview 
    with Barbara Walters:
    Hepburn: “I have not lived as a woman. I have lived as a man… I’ve just done what I damn well wanted to and I made enough money to support myself. And I ain’t afraid of being alone.”
    Walters: “Is that why also you wear pants?”
    Hepburn: “No, I just wore pants because they’re comfortable.”
    Walters: “Do you ever wear a skirt, by the way?”
    Hepburn: “I have one.”
    Walters: “You have one.”
    Hepburn: “I’ll wear it to your funeral.”
    Via Old Hollywood
    The Evolution of Snoopy
     Image via Ooorachaelooo

    Image via Tastefully Offensive
    Instant Sofa
    Image via Jay Romero
    Image via Psychotic Humor
    Do You Like To Time Travel?
    Image via Shirtoid 

    And my guy has a really big schlong.
    Image Via Tales of the Sissy
    During their waking hours, they terrorize small boys in snowed-in hotels.
    During their waking hours they terrorize small boys in snowed-in hotels.
    Image via Tack-O-Rama 
    Image via Tack-O-Rama 
    How most of the world views "OZ"...
    Australia - The Reality
    Townsville, Australia Map
    Image via Vacations To Go
    This all is in aid of my friend Donna who is coming 
    for a visit from
    Townsville, Queensland, Australia
    Dunno why she'd ever want to leave...
    Image via Wtanet
    Townsville combines the lure of the tropics with the attractions of a major city. From diving in the Great Barrier Reef, trying your luck at the Casino, rafting white water rapids or simply lazing on golden beaches, Townsville offers the best of all worlds.

    Located in North Queensland's "dry tropics," Townsville and Magnetic Island boast an average of 300 days of sunshine each year. Combining this glorious sunshine with a relaxed lifestyle and a diversity of attractions, Townsville is the perfect choice for a North Queensland holiday experience.

    The city and its precincts are continually evolving. Discover the latest redevelopment along Flinders Street East - a mix of funky nightclubs including the The Sovereign, gay owned and operated hotel/nightclub. You'll also find bars and restaurants housed in beautiful heritage buildings.

    Dining is a serious business in Townsville. Take a wander down Palmer Street and find restaurants offering cuisines from around the world, prepared using the freshest local seafood and produce.

    The Strand is a world-class beachfront promenade custom-built for enjoyment. Along this palm tree studded stretch are bike and rollerblade paths, safe swimming beaches, pretty picnic spots, a water park and chic restaurants and bars with to-die-for water views.
    Townsville is also one of Queensland's premier event destinations, with an exciting annual line up of sporting, aquatic, historical and cultural events.
    Using Townsville as a holiday base, visitors can experience the natural wonders of the diverse North Queensland region through day tours, cruises or adventure excursions - all operating out of the city.

    The Townsville Region
    Townsville's many attractions include the world's largest living coral reef aquarium, an Australian native wildlife sanctuary, art galleries, museums, parks, restaurants and the spectacular Strand beachfront promenade.

    Townsville is also a vibrant region that encompasses beautiful coastal towns, rainforests, rugged Outback and country terrain. Appreciate the beauty of the city and nearby Magnetic Island from Castle Hill, the rugged mountain that gives Townsville a unique rustic appeal. But the charm of this lovely region expands further from the city of Townsville - head in any direction and you'll be rewarded.

    The Great Barrier Reef sprawls to the east, the Outback beckons to the west, islands and rain forest entice to the north while sugar cane and mango farming communities tempt in the south.

    The Townsville region's national parks are home to rare butterflies and birds, kangaroos, platypus and ancient trees. Many of these also boast beautiful waterfalls and swimming holes, exquisite areas that are reminiscent of a bygone era.

    There is also a rich history in this region that has been shaped by Aboriginal tribes, miners, pastoralists and war. Remnants of these bygone times are still evident in the beautiful colonial architecture, historic pubs, museums and displays of old gold mining machinery and cottages.
    The opportunities for exploration in the Townsville Region invite you. The city is the perfect stepping-off point to experience the wonders of the region - the outback, rainforests, magnificent waterfalls, tropical islands and of course, the Great Barrier Reef.                                 
    Text via Q Guide
    Wombats are friendly - even big ones!
    Image via Travel Journals
    Image via Mess and Noise 
    Image via Agent 27 
    Image via Q Guide
    Image via Q Guide 
    Image via Q Guide
    Image via Q Guide
    Image via Q Guide 
    Image via Q Guide 
    Meanwhile, further north...
    Image via A Laugh A Day

    to know!
    Do not Vaseline.
    “It feels kinda good too.”
    On the Beach
    Image via Boy Culture 
    Damn! Butt Floss looks painful.
    It's not too early to think about Christmas gifting.
    Spooooky Reading...

    Evil Little Stories: A Collection


    To add your comments, click on
    links to this post here or below. It will take you to a stand-alone copy of this page. There, you will find the comments box at the very bottom, so feel free to let 'er rip.